ADGRG3 (GPR97)
Adhesion G Protein-Coupled Receptor G3
Gene Information Card
| Symbol | ADGRG3 |
|---|---|
| Full Name | Adhesion G Protein-Coupled Receptor G3 |
| Gene Type | protein-coding |
| Chromosomal Location | 16q21 |
| NCBI Gene ID | 222 ncbi.nlm.nih.gov/gene/222 |
| Ensembl ID | ENSG00000131095 |
| UniProt ID | Q8IWK6 |
| OMIM ID | 604650 |
| HGNC ID | 4517 |
| Aliases | GPR97, PGR25 |
Description
ADGRG3 (Adhesion G Protein-Coupled Receptor G3), also known as GPR97, is a member of the adhesion G protein-coupled receptor (GPCR) family. It is characterized by a large extracellular N-terminal domain containing adhesion-like motifs. The receptor is involved in cell adhesion, migration, and signaling, and is expressed in various tissues including the brain, immune cells, and reproductive organs. ADGRG3 has been implicated in immune regulation and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of ADGRG3 may promote tumor cell migration and invasion via GPCR signaling pathways. | COSMIC; PMID: 25691885 |
| Prostate cancer | ADGRG3 expression is altered in prostate cancer tissues, potentially affecting androgen receptor signaling. | COSMIC; PMID: 27387371 |
| Inflammatory bowel disease | ADGRG3 variants may influence immune cell adhesion and gut inflammation. | ClinVar; PMID: 28067908 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Medium |
| Lung | 3.8 | Low |
| Spleen | 6.1 | Medium |
| Testis | 4.5 | Low |
| Prostate | 7.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.9 | Low expression |
| K562 | 8.3 | Medium expression |
| MCF7 | 6.7 | Medium expression |
| LNCaP | 5.5 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1003C>T (p.Arg335Trp) | Missense | 0.001% (gnomAD) | Unknown functional effect; reported in ClinVar as uncertain significance |
| c.1456G>A (p.Gly486Ser) | Missense | 0.002% (gnomAD) | May alter receptor activation; limited evidence |
| c.1789_1791del (p.Phe597del) | In-frame deletion | <0.001% | Reported in COSMIC in colorectal cancer samples |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ADGRG3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • cell adhesion (GO:0007155) |
| • plasma membrane (GO:0005886) | • signal transduction (GO:0007165) |
| • receptor for retinoic acid (GO:0001974) |
Pathways
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Adhesion GPCR signaling (Reactome: R-HSA-500792)
Protein Summary
ADGRG3 encodes a 7-transmembrane adhesion GPCR with a large extracellular domain containing a GPS (GPCR proteolysis site) motif. The protein undergoes autoproteolytic cleavage at the GPS site, resulting in an N-terminal fragment (NTF) and a C-terminal fragment (CTF) that remain non-covalently associated. ADGRG3 is involved in cell-cell and cell-matrix adhesion, and its signaling modulates cell migration and immune responses. Expression is enriched in brain, spleen, and reproductive tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADGRG3 Knockout HEK293 Cell Line | EDJ-KQ9017 | Human | 222487 | Details Get a Quote |
| ADGRG3 Knockout HeLa Cell Line | EDJ-KQ59187 | Human | 222487 | Details Get a Quote |
| ADGRG3 Knockout A-549 Cell Line | EDJ-KQ67656 | Human | 222487 | Details Get a Quote |
| ADGRG3 Knockout HCT 116 Cell Line | EDJ-KQ76043 | Human | 222487 | Details Get a Quote |
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