ADGRF3 Gene: Adhesion G Protein-Coupled Receptor F3 | Function & Disease

ADGRF3 (Adhesion G Protein-Coupled Receptor F3) is a protein-coding gene that encodes a member of the adhesion G protein-coupled receptor (GPCR) family. These receptors are characterized by a long N-terminal extracellular domain with multiple adhesion-like motifs, which mediate cell-cell and cell-matrix interactions. ADGRF3 is involved in cellular signaling and may play a role in sensory perception, particularly in taste and olfactory systems. The gene is located on chromosome 2p23.3 and is expressed in various tissues, including the brain and testis.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• GPCR downstream signaling

The ADGRF3 protein (UniProt Q8IZF7) is a 1011-amino acid adhesion GPCR with a large extracellular N-terminus containing a GPS (GPCR proteolysis site) domain. It is predicted to undergo autoproteolytic cleavage at the GPS motif, producing an N-terminal fragment and a C-terminal seven-transmembrane domain. The protein is involved in cell adhesion and signaling, though its specific ligands and physiological functions remain largely uncharacterized.