ADGRF1 (Adhesion G Protein-Coupled Receptor F1)
A comprehensive biomedical overview of the ADGRF1 gene, including genomic context, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | ADGRF1 |
|---|---|
| Full Name | Adhesion G Protein-Coupled Receptor F1 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | Q5T4S7 |
| OMIM ID | 617259 |
| HGNC ID | 24830 |
| Aliases | GPR110, KPG_003, PGR19 |
Description
ADGRF1 (Adhesion G Protein-Coupled Receptor F1), formerly known as GPR110, is a member of the adhesion GPCR family. The gene is located on chromosome 6p21.1 and encodes a protein with a large extracellular N-terminal domain containing adhesion-like motifs. ADGRF1 is involved in cell adhesion, signaling, and has been implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Overexpression of ADGRF1 promotes tumor growth and metastasis via GPCR signaling | PMID: 25605247 |
| Breast cancer | ADGRF1 expression correlates with poor prognosis; activates MAPK/ERK pathway | PMID: 27323851 |
| Prostate cancer | ADGRF1 is upregulated and associated with androgen receptor signaling | PMID: 28476882 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Prostate | 15.2 | Medium |
| Brain | 3.1 | Not detected |
| Liver | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung) | 18.4 | High expression |
| MCF7 (breast) | 9.7 | Moderate expression |
| PC3 (prostate) | 21.0 | High expression |
| HEK293 (embryonic kidney) | 2.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.567_568insA (p.Glu190fs) | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Glu190fs) are predicted to cause loss of function by truncating the protein.
Gain of Function (GOF)
Missense mutations such as p.Arg412Cys may alter receptor activity, but evidence for gain-of-function is limited.
Dominant Negative (DN)
No dominant-negative mutations have been reported for ADGRF1.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor signaling pathway | • cell adhesion |
| • plasma membrane | • integral component of membrane |
Pathways
• GPCR signaling
• MAPK/ERK pathway
Protein Summary
The ADGRF1 protein is a 7-transmembrane adhesion GPCR with a large extracellular domain. It undergoes autoproteolytic cleavage at the GPCR proteolysis site (GPS) to generate an N-terminal fragment and a C-terminal fragment that remain non-covalently associated. The protein is involved in cell-cell and cell-matrix adhesion and activates downstream signaling cascades, including the MAPK/ERK pathway.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADGRF1 Knockout HEK293 Cell Line | EDJ-KQ12291 | Human | 266977 | Details Get a Quote |
| ADGRF1 Knockout HCT 116 Cell Line | EDJ-KQ41100 | Human | 266977 | Details Get a Quote |
| ADGRF1 Knockout HeLa Cell Line | EDJ-KQ59358 | Human | 266977 | Details Get a Quote |
| ADGRF1 Knockout A-549 Cell Line | EDJ-KQ67820 | Human | 266977 | Details Get a Quote |
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