ADGRE3 (Adhesion G Protein-Coupled Receptor E3)
Gene encoding a member of the adhesion GPCR family involved in cell adhesion and signaling
Gene Information Card
| Symbol | ADGRE3 |
|---|---|
| Full Name | Adhesion G Protein-Coupled Receptor E3 |
| Gene Type | Protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 84658 ncbi.nlm.nih.gov/gene/84658 |
| Ensembl ID | ENSG00000131355 |
| UniProt ID | Q9BY15 |
| OMIM ID | 606101 |
| HGNC ID | 3357 |
| Aliases | EMR3, EGF-like module receptor 3 |
Description
ADGRE3 (Adhesion G Protein-Coupled Receptor E3), also known as EMR3, encodes a member of the adhesion G protein-coupled receptor (GPCR) family. The protein contains multiple N-terminal EGF-like domains and a GPCR proteolytic site (GPS) domain, characteristic of adhesion GPCRs. It is involved in cell-cell adhesion and immune cell interactions, particularly in myeloid cells. The gene is located on chromosome 19p13.2.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 6.2 | Low |
| Spleen | 5.8 | Low |
| Bone marrow | 4.5 | Low |
| Whole blood | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocytic leukemia) | 8.0 | Myeloid cell line |
| HL-60 (promyeloblast) | 6.5 | Myeloid cell line |
| K-562 (erythroleukemia) | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations documented in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • cell adhesion (GO:0007155) |
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
Pathways
• Adhesion GPCR signaling (Reactome: R-HSA-500792)
Protein Summary
The ADGRE3 protein (UniProt Q9BY15) is a 693-amino acid adhesion GPCR with a large extracellular region containing EGF-like domains, a GPS domain, and a seven-transmembrane domain. It is expressed predominantly in myeloid cells and may mediate cell-cell adhesion and immune surveillance. No disease associations or pathogenic mutations have been established.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ADGRE3 Knockout HEK293 Cell Line | EDJ-KQ10151 | Human | 84658 | Details Get a Quote |
| ADGRE3 Knockout HeLa Cell Line | EDJ-KQ57634 | Human | 84658 | Details Get a Quote |
| ADGRE3 Knockout A-549 Cell Line | EDJ-KQ66131 | Human | 84658 | Details Get a Quote |
| ADGRE3 Knockout HCT 116 Cell Line | EDJ-KQ74557 | Human | 84658 | Details Get a Quote |
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