ADGRA3 Gene: Adhesion G Protein-Coupled Receptor A3 | NCBI, UniProt, OMIM

ADGRA3 (Adhesion G Protein-Coupled Receptor A3) encodes a member of the adhesion GPCR family, characterized by a long N-terminal extracellular domain with multiple adhesion-like motifs. The receptor is involved in cell-cell and cell-matrix interactions, and may play roles in development, angiogenesis, and tumorigenesis. Expression is enriched in testis, brain, and certain cancer cell lines.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Adhesion GPCR signaling (Reactome R-HSA-500792)

• GPCR downstream signaling (Reactome R-HSA-388396)

ADGRA3 is a 1,200-amino acid adhesion GPCR with a large extracellular region containing a GPS (GPCR proteolysis site) domain, a seven-transmembrane domain, and a cytoplasmic tail. It undergoes autoproteolytic cleavage at the GPS motif, producing an N-terminal fragment (NTF) and a C-terminal fragment (CTF) that remain non-covalently associated. The protein mediates cell adhesion and may activate G proteins (e.g., Gα12/13) to modulate Rho signaling. Expression is highest in testis and brain, with aberrant expression in several cancers.