ACTR1B (ARP1 Actin-Related Protein 1 Homolog B)
Component of the dynactin complex essential for cytoplasmic dynein function and intracellular transport
Gene Information Card
| Symbol | ACTR1B |
|---|---|
| Full Name | actin related protein 1B |
| Gene Type | protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 10120 ncbi.nlm.nih.gov/gene/10120 |
| Ensembl ID | ENSG00000115073 |
| UniProt ID | P42025 |
| OMIM ID | 605454 |
| HGNC ID | 167 |
| Aliases | ARP1, ARP1B, CTRN2 |
Description
ACTR1B encodes ARP1, a minor actin-related protein that is a core component of the dynactin complex. Dynactin binds to both microtubules and cytoplasmic dynein, linking dynein to cargo and enhancing its processivity. ARP1 forms a short actin-like filament within dynactin that is essential for dynein-mediated retrograde transport of vesicles, organelles, and macromolecules along microtubules.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Amyotrophic lateral sclerosis (ALS) | Dynactin dysfunction impairs axonal transport, leading to motor neuron degeneration | PMID: 12829703 |
| Peripheral neuropathy | Mutations in dynactin subunits disrupt retrograde transport in neurons | PMID: 14634665 |
| Neurodegenerative disorders | Impaired dynein/dynactin transport contributes to protein aggregation and neuronal death | PMID: 16936732 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
| Lung | 7.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.8 | Embryonic kidney cells |
| HeLa | 11.2 | Cervical cancer cells |
| K562 | 9.5 | Leukemia cells |
| SH-SY5Y | 16.3 | Neuroblastoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.172C>T (p.Arg58Trp) | Missense | <0.01% | Unknown functional effect; rare population variant |
| c.425G>A (p.Arg142His) | Missense | <0.01% | Reported in ALS patients; potential loss of dynactin function |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair ARP1 incorporation into dynactin, reducing dynein processivity.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
Mutations in dynactin subunits can act dominant-negatively by disrupting complex assembly.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005200 ~ structural constituent of cytoskeleton | • GO:0005856 ~ cytoskeleton |
| • GO:0005869 ~ dynactin complex | • GO:0007018 ~ microtubule-based movement |
| • GO:0030030 ~ cell projection organization | • GO:0030705 ~ cytoskeleton-dependent intracellular transport |
Pathways
• REACT:2131691 ~ Dynein-mediated cargo transport
• REACT:111045 ~ Microtubule-dependent transport
• KEGG:04810 ~ Regulation of actin cytoskeleton
Protein Summary
ARP1 (ACTR1B) is a 42 kDa actin-related protein that polymerizes into a short filament within the dynactin complex. It provides a scaffold for binding of other dynactin subunits and interacts with microtubules via the CAP-Gly domain of p150Glued. ARP1 is essential for the processive movement of cytoplasmic dynein along microtubules and for proper localization of endosomes, lysosomes, and Golgi vesicles.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACTR1B Knockout HEK293 Cell Line | EDJ-KQ6266 | Human | 10120 | Details Get a Quote |
| ACTR1B Knockout A-549 Cell Line | EDJ-KQ31524 | Human | 10120 | Details Get a Quote |
| ACTR1B Knockout HCT 116 Cell Line | EDJ-KQ31526 | Human | 10120 | Details Get a Quote |
| ACTR1B Knockout HeLa Cell Line | EDJ-KQ31527 | Human | 10120 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
