ACTR10: Actin-Related Protein 10 Homolog
A component of the dynactin complex involved in intracellular transport and cytoskeletal organization.
Gene Information Card
| Symbol | ACTR10 |
|---|---|
| Full Name | actin related protein 10 homolog |
| Gene Type | protein coding |
| Chromosomal Location | 14q23.1 |
| NCBI Gene ID | 55860 ncbi.nlm.nih.gov/gene/55860 |
| Ensembl ID | ENSG00000100823 |
| UniProt ID | Q9NZ32 |
| OMIM ID | 605405 |
| HGNC ID | 17372 |
| Aliases | ARP10, Arp10, HARP11 |
Description
ACTR10 (actin related protein 10 homolog) encodes a protein that is a component of the dynactin complex, which is essential for dynein-mediated vesicle and organelle transport along microtubules. The protein shares structural similarity with actin but is not thought to polymerize into filaments. It is involved in mitotic spindle orientation, cell migration, and intracellular trafficking.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Perry syndrome | Possible role in dynactin dysfunction; ACTR10 mutations not directly confirmed in Perry syndrome but dynactin subunit mutations are linked | ClinVar, OMIM |
| Neurodegenerative disorders | Dynactin complex dysfunction is implicated in motor neuron disease and neurodegeneration; ACTR10 may contribute indirectly | NCBI Gene, PubMed |
| Cancer (various) | Altered expression in certain cancers; role in cell migration and invasion via dynactin complex | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
| Lung | 7.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.4 | Cervical cancer cell line |
| HEK293 | 9.1 | Embryonic kidney cells |
| K562 | 7.6 | Leukemia cell line |
| HepG2 | 6.8 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | missense | <0.01% | Unknown; likely benign |
| c.512C>T (p.Pro171Leu) | missense | <0.01% | Unknown; likely benign |
| c.784G>A (p.Val262Ile) | missense | <0.01% | Unknown; likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ACTR10.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0003779 - actin binding | • GO:0005200 - structural constituent of cytoskeleton |
| • GO:0005856 - cytoskeleton | • GO:0005869 - dynactin complex |
| • GO:0015630 - microtubule cytoskeleton | • GO:0030030 - cell projection organization |
| • GO:0051010 - microtubule plus-end binding |
Pathways
• Dynactin complex assembly and function
• Microtubule-based intracellular transport
• Cytoskeletal signaling
Protein Summary
The ACTR10 protein (UniProt Q9NZ32) is a 376-amino-acid actin-related protein that localizes to the dynactin complex. It does not form filaments but participates in linking cargo to dynein motors. The protein is widely expressed, with highest levels in testis and brain. Its structure includes an actin-like fold but lacks key residues required for ATP binding and polymerization.
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