ACTL10: Actin-Like Protein 10
A cytoskeletal-related gene with limited functional characterization
Gene Information Card
| Symbol | ACTL10 |
|---|---|
| Full Name | actin-like 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q11.23 |
| NCBI Gene ID | 100130449 ncbi.nlm.nih.gov/gene/100130449 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | A6NHL2 |
| OMIM ID | - |
| HGNC ID | 37242 |
| Aliases | MGC26733, actin-like 10 |
Description
ACTL10 (actin-like 10) is a protein-coding gene located on chromosome 20q11.23. It encodes a protein that belongs to the actin family, which is involved in cytoskeletal structure and cellular motility. The specific function of ACTL10 is not fully characterized, but it is predicted to play a role in actin-related processes. Expression data suggest low to moderate levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated disease links in OMIM or ClinVar as of current data. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Prostate | 2.8 | Low |
| Lung | 2.5 | Low |
| Breast | 2.3 | Low |
| Testis | 12.4 | Medium |
| Brain (cerebellum) | 8.2 | Low |
| Thyroid | 6.5 | Low |
| Adrenal gland | 5.1 | Low |
| Lung | 3.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.0 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.0 | Low expression |
| HeLa | 5.2 | Low expression |
| K562 | 4.1 | Low expression |
| MCF7 | 3.8 | Low expression |
| HepG2 | 2.9 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not reported | No known effect |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
Loss of Function (LOF)
No evidence of loss-of-function mutations in human disease.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Protein Summary
The ACTL10 protein (UniProt A6NHL2) is a member of the actin-like family. It is predicted to have a role in cytoskeletal dynamics, though experimental validation is limited. The protein sequence shows homology to conventional actins but lacks known functional domains beyond the actin fold.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACTL10 Knockout HEK293 Cell Line | EDJ-KQ11506 | Human | 170487 | Details Get a Quote |
| ACTL10 Knockout A-549 Cell Line | EDJ-KQ41071 | Human | 170487 | Details Get a Quote |
| ACTL10 Knockout HCT 116 Cell Line | EDJ-KQ41073 | Human | 170487 | Details Get a Quote |
| ACTL10 Knockout HeLa Cell Line | EDJ-KQ41074 | Human | 170487 | Details Get a Quote |
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