ACP6 (Acid Phosphatase 6, Lysophosphatidic Acid Phosphatase)
Gene encoding a lysophosphatidic acid phosphatase involved in lipid metabolism and potential roles in cancer and neurological disorders.
Gene Information Card
| Symbol | ACP6 |
|---|---|
| Full Name | Acid Phosphatase 6, Lysophosphatidic Acid Phosphatase |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.2 |
| NCBI Gene ID | 51205 ncbi.nlm.nih.gov/gene/51205 |
| Ensembl ID | ENSG00000142875 |
| UniProt ID | Q9NPH0 |
| OMIM ID | 611471 |
| HGNC ID | 24032 |
| Aliases | ACPP, LPP, LPA phosphatase, lysophosphatidic acid phosphatase type 6 |
Description
ACP6 encodes a member of the acid phosphatase family that specifically hydrolyzes lysophosphatidic acid (LPA) to monoacylglycerol. This enzyme is involved in lipid metabolism and may regulate LPA signaling, which plays roles in cell proliferation, migration, and survival. ACP6 is expressed in various tissues and has been implicated in cancer and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered LPA metabolism via ACP6 may affect tumor growth and metastasis. | NCBI Gene, COSMIC |
| Neurological disorders | Potential role in LPA signaling in the nervous system; limited direct evidence. | NCBI Gene, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Liver | 3.8 | Low |
| Kidney | 4.1 | Low |
| Testis | 6.7 | Medium |
| Prostate | 8.9 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.5 | Embryonic kidney cells |
| HeLa | 3.2 | Cervical cancer cells |
| MCF7 | 5.1 | Breast cancer cells |
| A549 | 6.0 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional effect |
| c.458G>A (p.Arg153Gln) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0003993 - acid phosphatase activity | • GO:0008152 - metabolic process |
| • GO:0016787 - hydrolase activity | • GO:0042578 - phosphoric ester hydrolase activity |
| • GO:0046470 - phosphatidylcholine metabolic process |
Pathways
• Lysophosphatidic acid metabolism
• Glycerophospholipid metabolism
Protein Summary
ACP6 is a 453-amino acid protein with a molecular weight of approximately 50 kDa. It localizes to lysosomes and functions as a lysophosphatidic acid phosphatase, converting LPA to monoacylglycerol. The enzyme is active at acidic pH and is inhibited by tartrate. Its structure includes a conserved acid phosphatase domain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACP6 Knockout HEK293 Cell Line | EDJ-KQ10973 | Human | 51205 | Details Get a Quote |
| ACP6 Knockout A-549 Cell Line | EDJ-KQ37494 | Human | 51205 | Details Get a Quote |
| ACP6 Knockout HCT 116 Cell Line | EDJ-KQ38797 | Human | 51205 | Details Get a Quote |
| ACP6 Knockout HeLa Cell Line | EDJ-KQ38798 | Human | 51205 | Details Get a Quote |
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