ACKR5: Atypical Chemokine Receptor 5
Atypical chemokine receptor involved in immune regulation and chemokine scavenging.
Gene Information Card
| Symbol | ACKR5 |
|---|---|
| Full Name | Atypical Chemokine Receptor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 1230 ncbi.nlm.nih.gov/gene/1230 |
| Ensembl ID | ENSG00000121741 |
| UniProt ID | O00590 |
| OMIM ID | 602939 |
| HGNC ID | 1612 |
| Aliases | CCRL2, CKRX, CRAM-A, CRAM-B |
Description
ACKR5 (atypical chemokine receptor 5), also known as CCRL2, is a member of the atypical chemokine receptor family. It is a G protein-coupled receptor that binds chemokines but does not activate typical G protein signaling. Instead, it functions as a scavenger receptor, modulating chemokine gradients and immune cell trafficking. ACKR5 is expressed on various immune cells and is implicated in inflammatory responses and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory diseases | Modulation of chemokine gradients via scavenging | PMID: 23455675 |
| Cancer | Altered expression may affect tumor immune microenvironment | COSMIC ACKR5 mutations |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lymph node | 6.7 | Low |
| Bone marrow | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 | 15.2 | Monocytic cell line |
| U937 | 10.8 | Histiocytic lymphoma |
| Jurkat | 2.3 | T-cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T | missense | 0.01% | p.Thr67Ile, unknown significance |
| c.457G>A | missense | 0.005% | p.Gly153Ser, unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004930 - G protein-coupled receptor activity | • GO:0019957 - chemokine binding |
| • GO:0005886 - plasma membrane | • GO:0007165 - signal transduction |
| • GO:0006955 - immune response |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• GPCR ligand binding (Reactome: R-HSA-375276)
Protein Summary
ACKR5 is a 7-transmembrane domain receptor that binds chemokines such as CCL2, CCL5, and CCL7. It lacks the DRY motif required for G protein coupling, classifying it as an atypical receptor. It internalizes chemokines, contributing to chemokine gradient regulation. The protein is expressed on dendritic cells, macrophages, and neutrophils, playing roles in inflammation and immune surveillance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ACKR5 Knockout HEK293 Cell Line | EDJ-KQ7368 | Human | 11318 | Details Get a Quote |
| ACKR5 Knockout HeLa Cell Line | EDJ-KQ55629 | Human | 11318 | Details Get a Quote |
| ACKR5 Knockout A-549 Cell Line | EDJ-KQ64128 | Human | 11318 | Details Get a Quote |
| ACKR5 Knockout HCT 116 Cell Line | EDJ-KQ72573 | Human | 11318 | Details Get a Quote |
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